| Health Projects |
| LEGG-CALVE-PERTHES DISEASE RESEARCH REPORT (Report approved by CHF 8/2010, Received by sponsors 1/2011) |
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| ALL DONATIONS ARE TAX |
| SCA Rescue and Health Foundation |
Contributions to the Epilepsy and/or Legg-Calve Perthes Disease projects can be
made through the SCA Rescue and Health Foundation. Send tax deductible
contributions to June Moore, SCA Rescue and Health Foundation Treasurer, 5804
South Hwy 349, Midland, TX 79706-7636. We need to raise funds for both
research projects. SHOW YOUR SUPPORT by making your tax deductible
contributions now!
made through the SCA Rescue and Health Foundation. Send tax deductible
contributions to June Moore, SCA Rescue and Health Foundation Treasurer, 5804
South Hwy 349, Midland, TX 79706-7636. We need to raise funds for both
research projects. SHOW YOUR SUPPORT by making your tax deductible
contributions now!
| For complete information, use the links below. |
| SCHIPPERKE HAIR COAT DISORDER STUDY |
The Foundation has donated $3,730.00 towards this study. For more information, go
to http://vetmed.iastate.edu/vcs/research/clinical-trials
to http://vetmed.iastate.edu/vcs/research/clinical-trials
| CONTRIBUTIONS NEEDED TO HELP SUPPORT HEALTH RESEARCH PROJECTS |
The Schipperke Club of America Rescue and Health Foundation supported this
project. Although Schipperkes were not named in the research grant, Schipperke
samples will be accepted. We have already submitted DNA from 5 affected
Schipperke. More samples from affected Schipperkes are needed.
Report to Grant Sponsor from Investigator:
Legg-Calve-Perthes Disease (LCPD) is a debilitating orthopedic disease that is
primarily treated by surgical excision of the affected femoral head and neck of young
(<18 months of age) dogs. At least 26 breeds have reported LCPD occurrence. We
are initially focused on the West Highland White Terrier (WHWT), Yorkshire Terrier
(YT), and Cairn Terrier (CT) breeds, but our research has the potential to apply to
other terrier and small breeds. This study aims to dissect the genetic component(s) of
LCPD in terrier breeds through genomic analyses. Our strategy consists of collecting
blood samples from affected and normal terrier breeds, and completing a
whole-genome association study using a commercial SNP array. Genotypes for each
dog will be assigned using computer algorithms and analyzed using statistical
software. Genomic regions that produce statistically significant scores will be further
examined for candidate genes. Two hundred samples are anticipated for the
completion of this work: 100 normal and 100 LCPD-affected. Of these, 70 have
been collected (42 normal, 28 affected). Preliminary work has commenced with a
small number of dogs, however, additional samples from all three breeds - YT and
CT, in particular - are required to complete the full-scale analyses. Interested owners
willing to participate in the study are referred to submission forms and instructions
found at www.clemson.edu/cgr. Questions regarding this study should be directed to
Dr. Alison Starr, astarr@clemson.edu.
project. Although Schipperkes were not named in the research grant, Schipperke
samples will be accepted. We have already submitted DNA from 5 affected
Schipperke. More samples from affected Schipperkes are needed.
Report to Grant Sponsor from Investigator:
Legg-Calve-Perthes Disease (LCPD) is a debilitating orthopedic disease that is
primarily treated by surgical excision of the affected femoral head and neck of young
(<18 months of age) dogs. At least 26 breeds have reported LCPD occurrence. We
are initially focused on the West Highland White Terrier (WHWT), Yorkshire Terrier
(YT), and Cairn Terrier (CT) breeds, but our research has the potential to apply to
other terrier and small breeds. This study aims to dissect the genetic component(s) of
LCPD in terrier breeds through genomic analyses. Our strategy consists of collecting
blood samples from affected and normal terrier breeds, and completing a
whole-genome association study using a commercial SNP array. Genotypes for each
dog will be assigned using computer algorithms and analyzed using statistical
software. Genomic regions that produce statistically significant scores will be further
examined for candidate genes. Two hundred samples are anticipated for the
completion of this work: 100 normal and 100 LCPD-affected. Of these, 70 have
been collected (42 normal, 28 affected). Preliminary work has commenced with a
small number of dogs, however, additional samples from all three breeds - YT and
CT, in particular - are required to complete the full-scale analyses. Interested owners
willing to participate in the study are referred to submission forms and instructions
found at www.clemson.edu/cgr. Questions regarding this study should be directed to
Dr. Alison Starr, astarr@clemson.edu.
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